5 FU DPYD Genotyping, (Pharmacogenetics)

Detection of DPYD IVS14+1 G→A variants

Main indication:

Treatment with 5-fluorouracil (Fluoropyrimidines).

Test usage:

The test is used to confirm the clinical diagnosis of dihydropyrimidine dehydrogenase (DPD) deficiency in affected patients and for the dectection of the IVS14+1G→A mutation in asymptomatic carriers. Dihydropyrimidine Dehydrogenase (DPD) Gene Mutation Analysis - Partial or complete deficiency of DPD activity has been associated with an increased risk for severe adverse reactions when treated with pyrimidine-based chemotherapeutic agents, such as 5-fluorouracil (5-FU).