Thermo Scientific™ EMCS (N-ε-malemidocaproyl-oxysuccinimide ester)
On demand
Order number :
22308
Thermo Scientific™ EMCS (N-ε-malemidocaproyl-oxysuccinimide ester)
Thermo Scientific Pierce EMCS is an amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a medium-length spacer arm (9.4 angstroms).
Features
- Reactive groups: NHS ester and maleimide
- Reactive towards: amino and sulfhydryl groups
- C6-homolog of aliphatic spacer series which includes AMAS, BMPS, GMBS and EMCS
- NHS ester end couples with primary amines at pH 7-9 to form stable amide bonds
- Maleimides react with -SH groups at pH 6.5-7.5, forming stable thioether linkages
- Non-cleavable
- Water-insoluble (dissolve first in DMF or DMSO); compare to Sulfo-EMCS
- Increased sphere of coupling vs. GMBS
- Short aliphatic spacer has low potential for eliciting an immune response
There are no specifications
There are no report
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