API2/MALT1 t(11;18) Gene Fusion Probe Detection Kit (IVD)

API2/MALT1 t(11;18) Gene Fusion Probe Detection Kit (IVD)

The API2/MALT1 DNA-FISH probe is designed to detect the translocation between the API2 gene located at 11q21 and the MALT1 gene located at 18q21 using fluorescence in situ hybridization (FISH).  The translocation between the API2 and MALT1 gene, designated as t(11;18)(q21;q21), can be detected in around 15% of mucosa-associated lymphoid tissue (MALT) lymphomas, but varies in frequency based on primary tumor site.  In pulmonal and gastric MALT, t(11;18) is found more frequently (38-53% and 22-24%, respectively) and in these cases is almost always the only detected chromosomal abnormality.  When observed in gastric MALT lymphoma, t(11;18) is highly associated with a lack of response to antibiotic H pylori eradication treatment.