Applied Biosystems™ Axiom™ Biobank Plus Genotyping Array
On demandApplied Biosystems™ Axiom™ Biobank Plus Genotyping Array
The Axiom™ Biobank Plus Genotyping Arrays were designed by and for thought leaders in the human genetics community for high-throughput, high-value genotyping of large sample cohorts to explore the genetics of complex diseases and translational research with a single comprehensive low-cost solution.
GWAS
• Intelligent marker selection enables imputation of millions of additional SNPs
• The genomic content module of each array is optimized for specific populations and is customizable to any 1000 Genomes population study by adding additional markers of your choosing
Transplant
• Content specific for transplantation research including functional variants, loss-of-function markers, and copy number
• Immune function, including content covering the major histocompatibility complex (MHC), human leukocyte antigen (HLA), and killer-cell immunoglobulin-like receptors (KIR)
Pharmacogenomic markers
• Markers were selected to represent phases of absorption, distribution, metabolism, and excretion (ADME)
Inflammation and HLA
• Contains markers with evidence for association with autoimmune and inflammation
• Covers variants in genes in the HLA and KIR regions known to be important in immune response
Exome
• Rare, non-synonymous coding SNPs and indels in protein coding regions of the genome
• A majority of variants are rare with minor allele frequency (MAF) <1%
• Newly discovered loss-of-function content
• SNPs and indels identified from a sequencing initiative of 26,000 individuals
• Known disease-causing mutationseQTLs
• Markers that have known associations to RNA expression traits
• Captures unique eQTLs contained in the NCBI Genotype-Tissue Expression (GTEx) eQTL database, GEUVIDAS project, and several other discovery projects
Human disease
• Alzheimer-s disease, including coverage of ApoE
• Blood phenotypes
• Cancer common variants
• Cardiometabolic
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