Applied Biosystems™ Axiom™ Biobank Plus Genotyping Array

Applied Biosystems™ Axiom™ Biobank Plus Genotyping Array

The Axiom™ Biobank Plus Genotyping Arrays were designed by and for thought leaders in the human genetics community for high-throughput, high-value genotyping of large sample cohorts to explore the genetics of complex diseases and translational research with a single comprehensive low-cost solution.

GWAS

• Intelligent marker selection enables imputation of millions of additional SNPs

• The genomic content module of each array is optimized for specific populations and is customizable to any 1000 Genomes population study by adding additional markers of your choosing

Transplant

• Content specific for transplantation research including functional variants, loss-of-function markers, and copy number

• Immune function, including content covering the major histocompatibility complex (MHC), human leukocyte antigen (HLA), and killer-cell immunoglobulin-like receptors (KIR)

Pharmacogenomic markers

• Markers were selected to represent phases of absorption, distribution, metabolism, and excretion (ADME)

Inflammation and HLA

• Contains markers with evidence for association with autoimmune and inflammation

• Covers variants in genes in the HLA and KIR regions known to be important in immune response

Exome

• Rare, non-synonymous coding SNPs and indels in protein coding regions of the genome

• A majority of variants are rare with minor allele frequency (MAF) <1%

• Newly discovered loss-of-function content

• SNPs and indels identified from a sequencing initiative of 26,000 individuals

• Known disease-causing mutationseQTLs

• Markers that have known associations to RNA expression traits

• Captures unique eQTLs contained in the NCBI Genotype-Tissue Expression (GTEx) eQTL database, GEUVIDAS project, and several other discovery projects

Human disease

• Alzheimer-s disease, including coverage of ApoE

• Blood phenotypes

• Cancer common variants

• Cardiometabolic