Applied Biosystems™ Axiom™ Exome 319 Array Plate

Applied Biosystems™ Axiom™ Exome 319 Array Plate

Streamline your causal variant studies by enriching genome-wide association studies (GWAS) datasets with an extensive set of novel, rare, putative functional variants. The content was discovered in 16 major exome sequencing projects spanning a total of 12,000 samples.

Features

• Comprehensive content for highest discovery power

   - More than 300,000 coding SNPs including non-synonymous and synonymous SNPs as well as variants in splice and stop codons.

   - Approximately 30,000 single-base and complex indels from the draft Phase 1 1000 Genomes Project exome calls.

• Informative markers to enable integrated data analysis

   - AIMs: Ancestry informative markers to measure Latino and African American ancestry. All markers have low linkage disequilibrium (LD) and span all autosomes and chromosome X.

   - >GWAS tags: Includes over 5,000 SNPs reported in the NHGRI Catalog of Published Associations (August 2011) and additional unpublished hits from scientific collaborations.

   - High value: Contains other markers of interest, including DNA fingerprinting SNPs, human leukocyte antigen (HLA) genes, chromosome Y, mitochondrial DNA, and microRNA sequences.

• Customization to include your candidate genes

   - Include an additional 100,000 SNPs from your own candidate genes to meet your research needs. Choose from the Axiom Genomic Database of 11M genotype-tested markers, or include variants of your own choosing.

• Proven performance

   - The panel has been fully genotype-tested against stringent QC criteria to ensure high-quality data.

   - Every marker has been tested against approximately 1,200 samples to ensure high sample pass, call rate, and reproducibility.