Applied Biosystems™ Axiom™ Genome-Wide CHB 1 & CHB 2 Array Set Bundle
On demandApplied Biosystems™ Axiom™ Genome-Wide CHB 1 & CHB 2 Array Set Bundle
Axiom Genome-Wide Population-Optimized Human Arrays are genotyping panels that offer the best genetic coverage of rare and common variants for genome-wide disease association studies.
The Axiom Genome-Wide CHB 1 and CHB 2 Array Set Bundle contains the Axiom Genome-Wide CHB 1 Array Plate and the Axiom Genome-Wide CHB 2 Array Plate. The Axiom Genome-Wide CHB 1 Array Plate maximizes genomic coverage of common alleles (MAF >5%) of the Han Chinese genome. The Axiom Genome-Wide CHB 2 Array Plate is designed to target rare variants (MAF 2-5%) as a complement to Axiom Genome-Wide CHB 1 Array Plate. The Axiom Genome-Wide CHB 1 and CHB 2 Array Set Bundle enables the most comprehensive commercially available genome-wide coverage in CHB populations.
Features
Each array plate was designed to achieve ˜90% genomic coverage (r2 >0.8) in each target population, while covering markers with MAF of 1-5% in areas such as:
- Critical biological categories (e.g., coding SNPs)
- Biological processes (e.g., drug metabolizing genes)
- Disease categories (e.g., cardiovascular disease, cancer, immunity/inflammation, MHC, and CNS)
- Common and rare SNPs and insertions/deletions (indels) from the International HapMap Project, 1000 Genomes Project, and published disease associations
- Genotype-tested genomic content proven to give informative and reliable results
- Markers preselected for coverage in critical biological categories, such as coding SNPs, and biological pathways, such as drug metabolizing or cardiovascular genes
- High sample pass rate, call rate, and reproducibility
- Compatible with the Axiom 2.0 Reagent Kit, GeneTitan™ MC Instrument, automated or manual workflow, and Genotyping Console™ Software
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