Applied Biosystems™ Axiom™ Genome-Wide PanAFR Genotyping Bundle
On demandApplied Biosystems™ Axiom™ Genome-Wide PanAFR Genotyping Bundle
Axiom genome-wide population-optimized human arrays are genotyping panels that offer the best genetic coverage of rare and common variants for genome-wide disease association studies.
The Axiom Genome-Wide PanAFR Genotyping Bundle is the first array to offer pan-African genomic coverage, with ≥90% genetic coverage of common and rare variants (MAF >2%) of the Yoruba (West African) genome and >85% coverage of common and rare variants (MAF >2%) of the Luhya and Maasi (East African) genomes. This array set also offers high genomic coverage (>85%) in admixed populations with West African ancestry. This three- array set covering African populations was launched in 2011 and is not associated with the Africa array that was custom designed for the Sanger Institute in 2017.
Features
Each array plate was designed to achieve ˜90% genomic coverage (r2 >0.8) in each target population, while covering markers with MAF of 1-5% in areas such as:
- Critical biological categories (e.g., coding SNPs)
- Biological processes (e.g., drug metabolizing genes)
- Disease categories (e.g., cardiovascular disease, cancer, immunity/inflammation, MHC, and CNS)
- Common and rare SNPs and insertions/deletions (indels) from the International HapMap Project, 1000 Genomes Project, and published disease associations
- Genotype-tested genomic content proven to give informative and reliable results
- Markers preselected for coverage in critical biological categories, such as coding SNPs, and biological pathways, such as drug metabolizing or cardiovascular genes
- High sample pass rate, call rate, and reproducibility
- Compatible with the Axiom 2.0 Reagent Kit, GeneTitan™ MC Instrument, automated or manual workflow, and Genotyping Console™ Software
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