Corning® 5 g Tetracycline Hydrochloride, Powder

Corning® 5 g Tetracycline Hydrochloride, Powder

The tetracyclines consist of a polycyclic ring with differing side chains. They are a broad-spectrum class of antibiotics against aerobes and anaerobes. Members of this class inhibit protein synthesis by binding to the 30S ribosomal subunit thereby blocking the incoming aminoacyl-tRNA from attaching to the acceptor site on the mRNA-ribosome complex. The congener tetracycline is a product of Streptomyces aureofaciens fermentation. Tetracyclines are bacteriostatic and their effects are reduced by dilution and by chelation with divalent cations. The tetracyclines are broad-spectrum antibiotics, but resistance to one congener confers resistance to all congeners.