Gibco™ CTS™ NK-Xpander™ Medium 5 L
On demand
Order number :
A5019002
Gibco™ CTS™ NK-Xpander™ Medium, 5 L
Gibco CTS NK-Xpander Medium is specifically formulated for superior expansion of human natural killer (hNK) cells for cell therapy applications. When hNK cells are enriched from human peripheral blood mononuclear cells (hPBMCs) and expanded in a feeder-free system using CTS NK-Xpander Medium supplemented with 5% hAB serum and 500U/mL IL-2 , ≥90% of the hNK cells generated maintain CD56+/CD16+/CD3- surface marker expression. Furthermore, such hNK cells demonstrate degranulation and killing of K562 cancer cells
Features
Superior expansion potential
- CTS NK-Xpander Medium is capable of producing a high yield of hNK cells without the need for feeder cells, providing robust expansion of enriched hNK cells from hPBMCs from qualified donors at day 14 to 15 versus other medium options. Cells maintain CD56+/CD16+/CD3- surface marker expression and demonstrate cytolytic capabilities
Manufactured for cell therapy applications
- CTS NK-Xpander Medium is manufactured without cytokines and growth factors to allow flexibility with regard to intended application. The medium does not include human or animal-derived components; however, supplementation with hAB serum is recommended for best results
CTS quality
- Gibco CTS products follow USP <1043> 'ancillary materials for cell, gene, and tissue-engineered products' within the responsibilities applicable to a supplier.* Documentation such as specific intended-use statements, full documentation traceability, and convenient access to our Drug Master File (DMF) are available to support your regulatory filing
Closed-system compatibility
- CTS NK-Xpander Medium is available in 500-mL-bottle and 5-L-bag formats for convenient process development and closed-system manufacturing scale-up. The 5-L bioprocess container chamber is constructed from Aegis 5-14 film and includes sterile, weldable DEHP-free PVC tubing with Luer lock and C-Flex™ tubing with MPC quick connector providing versatile connection options for your manufacturing process, including compatibility with the CTS Rotea Counterflow Centrifugation System
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