Gibco™ Dynamis™ Medium

Gibco™ Dynamis™ Medium

Gibco Dynamis liquid medium is specifically designed to offer the highest batch and fed-batch culture performance and yield with recombinant CHO cells in a chemically defined environment. Gibco Dynamis medium has also been shown to support robust growth of HEK293 cells for adenovirus production. The chemically defined, protein-free, animal origin component-free formulation provides the power to achieve high titers, start process development faster and streamline or simplify transfer to manufacturing scale

Features

Power to achieve higher titers

• Dynamis Medium is fortified to help maximize recombinant CHO cell growth and protein expression in suspension batch culture, offering 170% greater production than select competitive media with simple glucose supplementation by day 14. Cultures grown in Dynamis Medium extend to even higher titers demonstrating good cell viability out to day 21. This medium can also provide up to 60% greater fed-batch growth and production over glucose-only fed-batch culture for selected cell lines and applications when used with EfficientFeed C+ Supplement.

Power to start process development faster

• As a fortified medium, Dynamis provides the power to get to a high cell density over 10 million cells per mL faster than competitive products and sustains that cell density longer by just maintaining glucose levels. The viable cell growth achieved make it a good choice for scale-up if you have started with CD FortiCHO medium. When paired with EfficientFeed C+ Supplement, it provides a fast and efficient way to develop a process.

Using Dynamis Medium

• The cell line you are using is a transfected CHO K1, GS CHO or CHO-S cell line
• The cell line you are using is HEK293 for adenovirus production
• Maximum batch culture cell densities and protein titers are needed
• You have time to adapt cells into a new medium in an effort to maximize titers
• Cell health at harvest is a priority for downstream processing

Contents

• Liquid format medium. Store in the dark at 2–8°C