Invitrogen 25 µg Ki-67 Monoclonal Antibody (SolA15), Alexa Fluor 660, eBioscience™

Invitrogen 25 µg Ki-67 Monoclonal Antibody (SolA15), Alexa Fluor 660, eBioscience™

The monoclonal antibody SolA15 recognizes mouse and rat Ki-67, a 300 kDa nuclear protein. Ki-67 is present during all active phases of the cell cycle (G1, S, G2, and mitosis), but is absent from resting cells (G0). Ki-67 is detected within the nucleus during interphase but redistributes to the chromosomes during mitosis. Ki-67 is used as a marker for determining the growth fraction of a given population of cells. In studies of tumor cells, the "Ki-67 labeling index" refers to the number of Ki-67 positive cells within the population and this is used to predict outcome of particular cancer types. Ki-67 has been shown to interact with the DNA-bound protein chromobox protein homolog 3 (CBX3) (heterochromatin).

Alexa Fluor 660 emits at 690 nm and is intended for use on spectral cytometers where it may be multiplexed with APC, Alexa Fluor 647 and Alexa Fluor 700.

• Recommended Isotype Control: Rat IgG2a kappa Isotype Control (eBR2a), Alexa Fluor 660, eBioscience™