Invitrogen CD127 Monoclonal Antibody (eBioRDR5), Unconjugated, 100 µg, eBioscience™

Invitrogen CD127 Monoclonal Antibody (eBioRDR5), Unconjugated, 100 µg, eBioscience™

The eBioRDR5 monoclonal antibody reacts with human CD127 (Interleukin-7 Receptor alpha). CD127 complexes with CD132, also known as the common gamma chain (gamma c), to form the multi-functional IL-7 receptor (IL-7R). CD127 is a type I glycoprotein with a molecular weight of 75-80 kDa and is expressed by immature B cells through the early pre-B stage, by thymocytes during several stages of their development, and on most mature T cells, with transient down-regulation upon activation. Binding of IL-7 results in signal transduction which occurs through several tyrosine kinase pathways including the Jak/STAT pathway. IL-7 is indispensible for the development of lymphocytes, and the control of homeostatic proliferation of T-cells in the periphery. In addition, IL-7R signaling is know to be involved in the regulation of T cell receptor (TCR) locus rearrangement in gamma delta T cells.

Features

• Purity: Greater than 90%, as determined by SDS-PAGE.
• Aggregation: Less than 10%, as determined by HPLC.
• Filtration: 0.2 µm post-manufacturing filtered.