Invitrogen CD40 Monoclonal Antibody (1C10), Functional Grade, 5 mg, eBioscience™

Invitrogen CD40 Monoclonal Antibody (1C10), Functional Grade, 5 mg, eBioscience™

The 1C10 monoclonal antibody reacts with mouse CD40, a 45-50 kDa type I transmembrane glycoprotein. CD40 is a member of the TNFR family and is expressed by mouse B lymphocytes, follicular dendritic cells, thymic epithelium, and a subset of peripheral T cells. CD40 regulates B cell development/maturation by inducing Ig isotype switching and in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. Interaction of CD40 with CD154 (gp39), its ligand on T cells, is important in T-B cell crosstalk and plays a role in costimulation and immune regulation.

Applications: Functional Assay (FN).

Features  

• Filtration: 0.2 µm post-manufacturing filtered.
• Recommended Isotype Control: Rat IgG2a kappa Isotype Control (eBR2a), Functional Grade, eBioscience™.