Invitrogen FOXP3 Monoclonal Antibody (FJK-16s), PE-Cyanine5, 100 µg, eBioscience™
On demandInvitrogen FOXP3 Monoclonal Antibody (FJK-16s), PE-Cyanine5, 100 µg, eBioscience™
The FJK-16s antibody reacts with mouse, rat, dog, porcine, bovine and cat Foxp3 also known as FORKHEAD BOX P3, SCURFIN, and JM2; cross reactivity of this antibody to other proteins has not been determined. Foxp3, a 49-55 kDa protein, is a member of the forkhead/winged-helix family of transcriptional regulators, and was identified as the gene defective in 'scurfy' (sf) mice. Constitutive high expression of foxP3 mRNA has been shown in CD4+CD25+ regulatory T cells (Treg cells), and ectopic expression of foxp3 in CD4+CD25- cells imparts a Treg phenotype in these cells.
Immunoblotting with FJK-16s antibody has mapped the epitope to amino acids 75-125 of the mouse Foxp3 protein. In the human, this region has been shown to be alternatively spliced at the mRNA level. Both the alternatively-spliced and non-spliced isoforms are present in the CD4+CD25+ subset of lymphocytes. Preliminary RT-PCR experiments have not revealed this alternatively-spliced isoform in mouse splenocytes, suggesting different gene regulation in the mouse and human.
Features
- Excitation: 488-561 nm; Emission: 667 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.
- Filtration: 0.2 µm post-manufacturing filtered.
- Recommended Isotype Control: Rat IgG2a kappa Isotype Control (eBR2a), PE-Cyanine5, eBioscience™.
There are no specifications
There are no report
You May Also Like
Invitrogen CD4 Monoclonal Antibody (SK3 (SK-3)), NovaFluor Blue 610-30S, 25 Tests, eBioscience™
$ On demand
On demand
Invitrogen 100 µg CD133 (Prominin-1) Monoclonal Antibody (13A4), PerCP-eFluor 710, eBioscience™
$ On demand
On demand
Invitrogen CD16 Monoclonal Antibody (eBioCB16 (CB16)), eFluor™ 506, 100 Tests, eBioscience™
$ On demand
On demand
Invitrogen Mouse IgG2b kappa Isotype Control (eBMG2b), Functional Grade, 100 µg, eBioscience™
$ On demand
On demand
Invitrogen CD90.2 (Thy-1.2) Monoclonal Antibody (53-2.1), APC, 50 µg, eBioscience™
$ 193
On demand
Invitrogen CD45RO Monoclonal Antibody (UCHL1), PE, 100 Tests, eBioscience™
$ 295
On demand
Invitrogen 50 µg Rat IgG2a kappa Isotype Control (eBR2a), Alexa Fluor 561, eBioscience™
$ On demand
On demand
Invitrogen CD25 Monoclonal Antibody (BC96), APC, 100 Tests, eBioscience™
$ On demand