Invitrogen Granzyme B Monoclonal Antibody (NGZB), eFluor™ 450, 100 µg, eBioscience™
On demandInvitrogen Granzyme B Monoclonal Antibody (NGZB), eFluor™ 450, 100 µg, eBioscience™
This NGZB monoclonal antibody reacts with mouse Granzyme B, which is a member of the granzyme serine protease family. Granzyme B is found in the granules of cytotoxic T cells and NK cells. Granzyme B has also been described as CGL1 (cathepsin G-like-1), a serine protease expressed only in cytotoxic T-lymphocytes after cell activation, and CTLA-1 (cytotoxic T lymphocyte-associated serine esterase 1) based on identification of mRNA in various cytotoxic T cells, but not observed in non-cytotoxic lymphoid cells. Granzyme B is crucial for the rapid induction of target cell death by apoptosis, induced by interaction with cytotoxic T cells. The receptor involved has been identified as mannose 6-phosphate receptor. This receptor functions as a death receptor for Granzyme B during cytotoxic T cell-induced apoptosis. This NGZB monoclonal antibody does not crossreact to human Granzyme B nor is staining blocked with GB11, suggesting it recognizes a different epitope.
Features
- eFluor® 450 is an alternative to Pacific Blue®. eFluor® 450 emits at 445 nm and is excited with the Violet laser (405 nm). Please make sure that your instrument is capable of detecting this fluorochome.
- Excitation: 405 nm; Emission: 445 nm; Laser: Violet Laser.
- Filtration: 0.2 µm post-manufacturing filtered.
- Recommended Isotype Control: Rat IgG2a kappa Isotype Control (eBR2a), eFluor™ 450, eBioscience™.
There are no specifications
There are no report
You May Also Like
Invitrogen CD49f (Integrin alpha 6) Monoclonal Antibody (eBioGoH3 (GoH3)), PE, 50 µg, eBioscience™
$ 142
On demand
Invitrogen 25 µg Rat IgG2a kappa Isotype Control (eBR2a), eFluor 660, eBioscience™
$ On demand
On demand
Invitrogen 200 µg MHC Class II (I-A/I-E) Monoclonal Antibody (M5/114.15.2), PE, eBioscience™
$ On demand
On demand
Invitrogen IL-22 Monoclonal Antibody (IL22JOP), Functional Grade, 5 mg, eBioscience™
$ On demand
On demand
Invitrogen CD11c Monoclonal Antibody (N418), Alexa Fluor 660, 25 µg, eBioscience™
$ On demand
On demand
Invitrogen CD16 Monoclonal Antibody (eBioCB16 (CB16)), Super Bright™ 436, 25 Tests, eBioscience™
$ On demand
On demand
Invitrogen CD140a (PDGFRA) Monoclonal Antibody (APA5), FITC, 100 µg, eBioscience™
$ On demand