Invitrogen Granzyme B Monoclonal Antibody (NGZB), PE, 100 µg, eBioscience™
On demandInvitrogen Granzyme B Monoclonal Antibody (NGZB), PE, 100 µg, eBioscience™
This NGZB monoclonal antibody reacts with mouse Granzyme B, which is a member of the granzyme serine protease family. Granzyme B is found in the granules of cytotoxic T cells and NK cells. Granzyme B has also been described as CGL1 (cathepsin G-like-1), a serine protease expressed only in cytotoxic T-lymphocytes after cell activation, and CTLA-1 (cytotoxic T lymphocyte-associated serine esterase 1) based on identification of mRNA in various cytotoxic T cells, but not observed in non-cytotoxic lymphoid cells. Granzyme B is crucial for the rapid induction of target cell death by apoptosis, induced by interaction with cytotoxic T cells. The receptor involved has been identified as mannose 6-phosphate receptor. This receptor functions as a death receptor for Granzyme B during cytotoxic T cell-induced apoptosis. This NGZB monoclonal antibody does not crossreact to human Granzyme B nor is staining blocked with GB11, suggesting it recognizes a different epitope.
Features
- Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.
- Filtration: 0.2 µm post-manufacturing filtered.
- Recommended Isotype Control: Rat IgG2a kappa Isotype Control (eBR2a), PE, eBioscience™.
There are no specifications
There are no report
You May Also Like
Invitrogen 100 µg Ly-6G/Ly-6C Monoclonal Antibody (RB6-8C5), Super Bright 436, eBioscience™
$ On demand
On demand
Invitrogen 25 µg CD44 Monoclonal Antibody (IM7), eFluor 450, eBioscience™
$ On demand
On demand
Invitrogen c-Myc Monoclonal Antibody (9E10), DyLight 488, 50 µL
$ On demand
On demand
Invitrogen CD45 Monoclonal Antibody (30-F11), NovaFluor Red 700, 25 µg, eBioscience™
$ On demand
On demand
Invitrogen 500 µg CD45R (B220) Monoclonal Antibody (RA3-6B2), Functional Grade, eBioscience™
$ On demand
On demand
Invitrogen CD16 Monoclonal Antibody (eBioCB16 (CB16)), Super Bright™ 436, 100 Tests, eBioscience™
$ On demand
On demand
Invitrogen CD29 (Integrin beta 1) Monoclonal Antibody (eBioHMb1-1 (HMb1-1)), eFluor 450, 100 µg, eBioscience™
$ On demand