Invitrogen HIF-2 alpha Polyclonal Antibody, 100 µL

Invitrogen HIF-2 alpha Polyclonal Antibody, 100 µL

HIF-2 alpha (Epas1) is a transcription factor involved in the induction of genes regulated by oxygen. HIF-2 alpha contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. It also regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of the lungs. Mutations in this gene are associated with erythrocytosis familial type 4.

Suggested positive control: Cos7 CoCl2-treated nuclear extract, PC12 nuclear extracts.

Applications: ChIP assay (ChIP), Gel Shift (GS).