Invitrogen IL-1 beta (Pro-form) Monoclonal Antibody (NJTEN3), APC, 25 µg, eBioscience™
On demandInvitrogen IL-1 beta (Pro-form) Monoclonal Antibody (NJTEN3), APC, 25 µg, eBioscience™
This NJTEN3 monoclonal antibody reacts with the pro-form of mouse IL-1 beta, which is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. It is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is instead secreted alongside caspase-1 via an alternate and incompletely understood mechanism. IL-1 beta signals via the IL-1RI, which is shared with IL-1 alpha. These cytokines play important roles in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses. Their activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions, giving IL-RA or IL-1 beta neutralizing antibodies potential therapeutical value.The NJTEN3 antibody recognizes only the pro-form of mouse IL-1 beta and does not see the active (cleaved) form.
Features
- Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser.
- Filtration: 0.2 µm post-manufacturing filtered.
- Recommended Isotype Control: Rat IgG1 kappa Isotype Control (eBRG1), APC, eBioscience™
There are no specifications
There are no report
You May Also Like
Invitrogen 25 µg CD45R (B220) Monoclonal Antibody (RA3-6B2), Alexa Fluor 700, eBioscience™
$ On demand
On demand
Invitrogen LYVE1 Monoclonal Antibody (ALY7), Alexa Fluor 488, 100 µg, eBioscience™
$ On demand
On demand
Invitrogen Rat IgG1 kappa Isotype Control (eBRG1), Super Bright 702, 25 µg, eBioscience™
$ On demand
On demand
Invitrogen HLA-DR Monoclonal Antibody (LN3), Brilliant Ultra Violet 805, 100 Tests, eBioscience™
$ On demand
On demand
Thermo Scientific™ LanthaScreen™ Tb-labeled Anti-Goat Antibody Kit, 25 µg
$ On demand
On demand
Invitrogen T-bet Monoclonal Antibody (eBio4B10 (4B10)), PE, 25 µg, eBioscience™
$ On demand
On demand
Invitrogen 25 µg MHC Class II (I-A/I-E) Monoclonal Antibody (M5/114.15.2), eFluor 450, eBioscience™
$ On demand
On demand
Invitrogen CD16 Monoclonal Antibody (eBioCB16 (CB16)), NovaFluor™ Red 710, 100 Tests, eBioscience™
$ On demand