Invitrogen™ LentiArray™ Human Cell Cycle CRISPR Library

Invitrogen™ LentiArray™ Human Cell Cycle CRISPR Library

The award-winning Invitrogen™ LentiArray™ Human Cell Cycle Library targets 1,444 genes with up to 4 gRNA per gene target (pooled in a single well) for a total of 5,776 gRNAs. Libraries are delivered as 100 μL of ready to use lentiviral particles per gene target with an average titer of 1x108 TU/mL (functional titer determined by antibiotic resistance) and are also available as glycerol stocks.

Cell cycle regulators are important to normal development and also play a role in the development of cancer, cardiovascular, inflammatory, and neurodegenerative diseases. The gene targets within the LentiArray Human Cell Cycle Library were selected using the most up-to-date genome databases, including the NCBI RefSeq database, and cross-referenced to the Gene Ontology Consortium (GO) database and/or the HUGO Gene Nomenclature Committee (HGNC), and include cyclin-dependent kinases, or CDKs, regulators of cell cycle progression such as CIP/KIP family proteins and members of the INK4 family of cell cycle inhibitors, proteins in the retinoblastoma family, and DNA replication factors such as the cell division cycle proteins (CDCs). The gRNA designs for each target were created using Thermo Fisher Scientific's proprietary gRNA design algorithm.

Contents

• 1 library set, 100 µL/target