MYC/IGH t(8;14) Gene Fusion Probe Detection Kit (IVD)

MYC/IGH t(8;14) Gene Fusion Probe Detection Kit (IVD)

This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients.

 IGH (Immunoglobulin Heavy Locus) is a Protein Coding gene. Diseases associated with IGH include Agammaglobulinemia 1, Autosomal Recessive and Follicular Lymphoma 1. Among its related pathways are Immune response CD16 signaling in NK cells and Immune response Lectin induced complement pathway.