Thermo Scientific™ EZ-Link™ BMCC-Biotin
On demand
Order number :
21900
Thermo Scientific™ EZ-Link™ BMCC-Biotin
Thermo Scientific EZ-Link BMCC-Biotin is a maleimide-activated, sulfhydryl-reactive biotinylation reagent with an extended spacer arm that contains a stabilizing cyclohexane group.
BMCC-Biotin is a maleimido-biotin compound for labeling protein cysteines and other molecules that contain sulfhydryl groups. This reagent specifically reacts with reduced thiols (-SH) in near-neutral buffers to form permanent (irreversible) thioether bonds. The unique feature of BMCC-Biotin is its spacer arm cyclohexane ring; this has a stabilizing effect that minimizes hydrolysis and degradation of the maleimide group until it has opportunity to conjugate with target thiols.
Features
- Protein labeling—biotinylate antibodies or other proteins for use in protein methods
- Membrane-permeable—can be used to label inside cells (intracellular)
- Thiol-reactive—reacts with sulfhydryls (-SH), such as the side-chain of cysteine (C)
- Maleimide-activated—perform reactions at pH 6.5 to 7.5 in buffers such as PBS
- Irreversible—forms permanent thioether bonds; spacer arm cannot be cleaved
- Solubility—must be dissolved in DMSO or DMF before further dilution in aqueous buffers
- Medium length—spacer arm (total length added to target) is 32.6 angstroms; contains cyclohexane ring, which stabilizes adjacent maleimide
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