Thermo Scientific™ PEG12-SPDP (PEGylated, long-chain SPDP crosslinker)

Thermo Scientific™ PEG12-SPDP (PEGylated, long-chain SPDP crosslinker)

Thermo Scientific Pierce PEG12-SPDP is a multifunctional crosslinker for protein conjugation via amine-to-amine or amine-to-sulfhydryl crosslinks that contain a 12-unit polyethylene glycol (PEG) group and a reducible (cleavable) disulfide bond.

Features

• Efficient amine conjugation—NHS ester provides effective conjugation to lysines, N-termini of peptides and other primary amines
• Reversible sulfhydryl conjugation—pyridyldithiol group enables disulfide linkage with reduced cysteines and other sulfhydryl groups, providing a stable but cleavable bond
• Polyethylene glycol—PEG groups are flexible, non-immunogenic, hydrophilic, and often enhance the solubility of attached molecules
• Spacer arm—connects primary amines and sulfhydryl targets at distances up to 54.1 angstroms; compare to PEG4-SPDP (25.7 angstroms)