Thermo Scientific™ TMT11-131C Label Reagent, 1 x 5 mg

Thermo Scientific™ TMT11-131C Label Reagent, 1 x 5 mg

Amine-reactive Thermo Scientific TMT11-131C increases sample multiplexing from 10-plex to 11-plex, enabling even greater throughput for protein identification and quantitative analysis by tandem mass spectrometry (MS).

The Tandem Mass Tag (TMT) reagents are specially designed to enable identification and quantitation of proteins in different samples using tandem mass spectrometry. The TMT11-131C tag structure is identical to the other TMT10pex tags, but the TMT11-131C mass reporter is labeled with only 13C isotopes. The addition of the TMT11-131C tag enables separation of the 131 mass reporter ion of the original TMT10plex reagents into N and C variants, creating an 11th channel for relative quantitation using high resolution Orbitrap MS instruments.

For Use With (Equipment): Mass Spectrometer

Features

• Multiplex—increases level of multiplexing from ten to eleven samples
• Robust—increased multiplex capability results in fewer missing quantitative values among samples and higher confidence among replicates
• Efficient—amine-reactive, NHS-ester-activated reagents ensure efficient labeling of all peptides regardless of protein sequence or proteolytic enzyme specificity
• Compatible—optimized for use with high resolution Thermo Scientific MS/MS platforms, such as the Q Exactive, Orbitrap Elite, and Orbitrap Fusion Tribrid instruments with data analysis fully supported by Proteome Discoverer 2.1