AML1/ETO [RUNX1/RUNX1T1 t(8; 21)] Gene Fusion Probe Detection Kit (IVD)

AML1/ETO [RUNX1/RUNX1T1 t(8; 21)] Gene Fusion Probe  Detection Kit (IVD)

RUNX1 is a transcription factor that forms a complex with the cofactor CBFB. This complex provides stability to the RUNX1 protein which is involved in the generation of hematopoietic stem cells and for their differentiation into myeloid and lymphoid lines. Loss of RUNX1 function has been shown to impair differentiation between myeloid and lymphoid lines often resulting in the development of leukemia.

RUNX1T1 (RUNX1 Partner Transcriptional Co-Repressor 1) is a Protein Coding gene. Diseases associated with RUNX1T1 include Acute Myeloid Leukemia With T(8;21)(Q22;Q22) Translocation and Myeloid Leukemia. Among its related pathways are NF-kappaB Signaling. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and identical protein binding.