PML/RARA Gene Fusion Probe Detection Kit (IVD)

PML/RARA Gene Fusion Probe  Detection Kit (IVD)

RARA (Retinoic Acid Receptor Alpha) is a Protein Coding gene. Diseases associated with RARA include Acute Promyelocytic Leukemia and Leukemia. Among its related pathways are Transcription Ligand-dependent activation of the ESR1/SP pathway and Nuclear Receptors in Lipid Metabolism and Toxicity. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein heterodimerization activity.

PML (PML Nuclear Body Scaffold) is a Protein Coding gene. Diseases associated with PML include Acute Promyelocytic Leukemia and Rabies. Among its related pathways are miRNA Regulation of DNA Damage Response and mTOR signaling pathway. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and transcription coactivator activity. 

The PML-RARA fusion is the result of a recurrent, balanced translocation between chromosomes 15 and 17, denoted as t(15;17)(q22;q12), and a diagnostic event in acute promyelocytic leukemia (APL). Both in vitro and in vivo studies have shown sensitivity to ATRA (all-trans retinoic acid) in APL patients harboring the PML-RARA fusion. Recent interest has been shown in combining ATRA and arsenic trioxide for treating these patients, and early results seem promising. However, newly discovered mutations in the B2 domain of PML have started to show conferred resistance to ATRA in these patients.