Applied Biosystems™ CytoScan™ Optima Training Kit
On demandApplied Biosystems™ CytoScan™ Optima Training Kit
Approximately 50% of miscarriages are caused by chromosomal abnormalities. Traditional cytogenetic techniques such as karyotyping and FISH are limited by cell culture failure and usually lack the appropriate sensitivity.
CytoScan™ Optima Suite has been designed with input from the cytogenetics community worldwide and empirically optimized from CytoScan HD Suite. CytoScan Optima Array offers whole-genome coverage for accurate detection of chromosomal abnormalities with increased probe coverage targeting 396 relevant regions for prenatal and miscarriage applications.
CytoScan Optima Suite includes arrays, reagents, and easy-to-use data analysis software for a cost-effective and streamLined analysis of your prenatal and product of conception (POC) samples.
Features
- Whole-chromosome aneuploidies and submicroscopic gains and losses. This POC sample shows a 46 MB duplication in blue followed by a submicroscopic 2.2 MB deletion in red. (Fig. 1)
- LOH/AOH. This sample shows three confirmed purple LOH/AOH segments of different sizes and locations. (Fig. 2)
- Triploidy and maternal cell contamination. This whole-genome view shows four lines in the allelic difference track concordant with a triploidy in this first trimester POC sample. (Fig. 3)
- Low-level mosaicism. An increase in the signal in chromosome 2 shows a ∼20% mosaic trisomy in this chorionic villi (CVS) sample. (Fig. 4)
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