EGFR HER1, (FISH)

Detection of 7p11 amplification 

Main indication:

NSCLC negative EGFR mutation \ GBM \ Breast.

Test usage:

Sequence alterations of the EGFR gene have frequently been identified in non-small cell lung carcinoma (NSCLC), primarily in those patients who were responsive to Gefitinib, an EGFR tyrosine kinase inhibitor. A higher elevation of EGFR mRNA transcript has been observed in prostate cancers than in benign prostate hyperplasia (BPH) and normal prostate tissues. Colorectal cancer (CRC) patients with high EGFR gene copy number have an increased likelihood to respond to cetuximab therapy. FISH can detect this rearrangement in either interphase or metaphase cells.