Gibco Human TRANCE (RANKL) Recombinant Protein
On demandGibco Human TRANCE (RANKL) Recombinant Protein
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.
Contents
Storage buffer
- 5mM sodium phosphate, pH 7.6
- 75mM NaCl
There are no specifications
There are no report
You May Also Like
Invitrogen™ Albumin from Bovine Serum (BSA), Tetramethylrhodamine conjugate
$ 338
On demand
Invitrogen™ Cholera Toxin Subunit B (Recombinant), Alexa Fluor™ 555 Conjugate, 500 µg
$ 1,780
On demand
Invitrogen™ Isolectin GS-IB4 From Griffonia simplicifolia, Alexa Fluor™ 594 Conjugate
$ 1,042