Invitrogen CD11c Monoclonal Antibody (N418), Functional Grade, 500 µg, eBioscience™

Invitrogen CD11c Monoclonal Antibody (N418), Functional Grade, 500 µg, eBioscience™

The N418 monoclonal antibody reacts with mouse CD11c, the integrin alphaX. CD11c non-covalently associates with beta2 integrin to form the CD11c/CD18 heterodimer. CD11c is expressed by dendritic cells, a subset of Intestinal Intraepithelial Lymphocytes (IEL) and some activated T cells. CD11c/CD18 binds to CD54, iC3b and fibrinogen and plays a role in leukocyte adhesive interactions. N418 binds to CD11c on splenic dendritic cells in the T-dependent areas of mouse spleen and precipitates a 150, 90 kDa heterodimer.

• Endotoxin: Less than 0.001 ng/ug antibody as determined by the LAL assay.
• Storage and handling: Use in a sterile environment.
• Filtration: 0.2 µm post-manufacturing filtered.
• Purity: Greater than 90%, as determined by SDS-PAGE.
• Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay.
• Aggregation: Less than 10%, as determined by HPLC.
• Recommended Isotype Control: Armenian Hamster IgG Isotype Control (eBio299Arm), Functional Grade, eBioscience™.