Invitrogen CD127 Monoclonal Antibody (eBioRDR5), Alexa Fluor 532, 100 Tests, eBioscience™
On demandInvitrogen CD127 Monoclonal Antibody (eBioRDR5), Alexa Fluor 532, 100 Tests, eBioscience™
The eBioRDR5 monoclonal antibody reacts with human CD127 (Interleukin-7 Receptor alpha). CD127 complexes with CD132, also known as the common gamma chain (gamma c), to form the multi-functional IL-7 receptor (IL-7R). CD127 is a type I glycoprotein with a molecular weight of 75-80 kDa and is expressed by immature B cells through the early pre-B stage, by thymocytes during several stages of their development, and on most mature T cells, with transient down-regulation upon activation. Binding of IL-7 results in signal transduction which occurs through several tyrosine kinase pathways including the Jak/STAT pathway. IL-7 is indispensible for the development of lymphocytes, and the control of homeostatic proliferation of T-cells in the periphery. In addition, IL-7R signaling is know to be involved in the regulation of T cell receptor (TCR) locus rearrangement in gamma delta T cells.
Features
- Alexa Fluor™ 532 is excited with the Green laser (532 nm) and emits at 561 nm. This cannot be used with the Yellow-Green laser (561 nm). We recommend using a 560/14 band pass filter. Please make sure that your instrument is capable of detecting this fluorochrome.
- Excitation: 532 nm; Emission: 561 nm; Laser: Green Laser.
- Recommended Isotype Control: Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Alexa Fluor 532, eBioscience™.
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