Invitrogen CD127 Monoclonal Antibody (eBioRDR5), Alexa Fluor 561, 25 Tests, eBioscience™
On demandInvitrogen CD127 Monoclonal Antibody (eBioRDR5), Alexa Fluor 561, 25 Tests, eBioscience™
The eBioRDR5 monoclonal antibody reacts with human CD127 (Interleukin-7 Receptor alpha). CD127 complexes with CD132, also known as the common gamma chain (gamma c), to form the multi-functional IL-7 receptor (IL-7R). CD127 is a type I glycoprotein with a molecular weight of 75-80 kDa and is expressed by immature B cells through the early pre-B stage, by thymocytes during several stages of their development, and on most mature T cells, with transient down-regulation upon activation. Binding of IL-7 results in signal transduction which occurs through several tyrosine kinase pathways including the Jak/STAT pathway. IL-7 is indispensible for the development of lymphocytes, and the control of homeostatic proliferation of T-cells in the periphery. In addition, IL-7R signaling is know to be involved in the regulation of T cell receptor (TCR) locus rearrangement in gamma delta T cells.
Features
- Alexa Fluor 561 emits at 575 nm and is intended for use on spectral cytometers where it may be multiplexed with both PE and PE-eFluor 610.
- Excitation: 558 nm; Emission: 575 nm; Laser: Yellow-Green Laser
- Recommended Isotype Control: Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Alexa Fluor 561, eBioscience™.
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