Invitrogen CD40 Monoclonal Antibody (1C10), Super Bright™ 436, 100 µg, eBioscience™

Invitrogen CD40 Monoclonal Antibody (1C10), Super Bright™ 436, 100 µg, eBioscience™

The 1C10 monoclonal antibody reacts with mouse CD40, a 45-50 kDa type I transmembrane glycoprotein. CD40 is a member of the TNFR family and is expressed by mouse B lymphocytes, follicular dendritic cells, thymic epithelium, and a subset of peripheral T cells. CD40 regulates B cell development/maturation by inducing Ig isotype switching and in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. Interaction of CD40 with CD154 (gp39), its ligand on T cells, is important in T-B cell crosstalk and plays a role in costimulation and immune regulation.

Features  

• Super Bright 436 can be excited with the violet laser line (405 nm) and emits at 436 nm. We recommend using a 450/50 bandpass filter, or equivalent. Please make sure that your instrument is capable of detecting this fluorochrome.
• When using two or more Super Bright dye-conjugated antibodies in a staining panel, it is recommended to use Super Bright Complete Staining Buffer to minimize any non-specific polymer interactions. Please refer to the datasheet for Super Bright Staining Buffer for more information.
• Excitation: 405 nm; Emission: 436 nm; Laser: Violet Laser.
• Recommended Isotype Control: Rat IgG2a kappa Isotype Control (eBR2a), Super Bright™ 436, eBioscience™.