Invitrogen CD41a Monoclonal Antibody (eBioMWReg30 (MWReg30)), Functional Grade, 25 mg, eBioscience™
On demandInvitrogen CD41a Monoclonal Antibody (eBioMWReg30 (MWReg30)), Functional Grade, 25 mg, eBioscience™
The eBioMWReg30 monoclonal antibody reacts with mouse CD41 (fibrinogen receptor, gpIIb, integrin alpha IIb). While initially thought to be expressed exclusively on the surface of platelets and megakaryocytes, it has been demonstrated that CD41 is also expressed on hematopoietic progenitors in the embryo, fetus and adult. CD41 associates with CD61 (gpIIIa, integrin beta III) to form a receptor which plays a major role in platelet function, including binding of several adhesion molecules such as fibrinogen, fibronectin and vitronectin.
Recently, the SLAM-family markers, CD48 and CD150 have been used to reliably identify hematopoietic stem cells (HSC). Specifically, it was found that CD150+CD48- bone marrow cells were highly efficient in their ability to confer long-term multi-lineage reconstitution in irradiated mice. Furthermore, the efficiency of reconstitution was enhanced when HSCs were further enriched through the exclusion of CD41+ cells. Thus, the use of CD150+CD48-CD41- as an expression profile efficiently identifies hematopoietic stem cells.
- Filtration: 0.2 µm post-manufacturing filtered.
- Purity: Greater than 90%, as determined by SDS-PAGE.
- Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay.
- Aggregation: Less than 10%, as determined by HPLC.
- Applications: Functional Assay (FN), Peptide Array (Array).
- Recommended Isotype Control: Rat IgG1 kappa Isotype Control (eBRG1), Functional Grade, eBioscience™.
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