Invitrogen CD62L (L-Selectin) Monoclonal Antibody (MEL-14), Functional Grade, 5 mg, eBioscience™

Invitrogen CD62L (L-Selectin) Monoclonal Antibody (MEL-14), Functional Grade, 5 mg, eBioscience™

The MEL-14 monoclonal antibody reacts with mouse CD62L, a 76 kDa member of the selectin family. CD62L is expressed by neutrophils, monocytes, and subsets of T, B, and NK cells and binds a number of glycosylated, fucosylated, sulfated sialylated glycoproteins including CD34, glycam-1 and MAdCam-1. These interactions mediate rolling of lymphocytes on activated endothelium at the sites of inflammation and homing of cells to the high endothelial venules (HEV) of peripheral lymphoid tissues.

Applications: Neutralization (Neu), Functional Assay (FN).

Features

• Storage and handling: Use in a sterile environment.
• Filtration: 0.2 µm post-manufacturing filtered.
• Purity: Greater than 90%, as determined by SDS-PAGE.
• Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay.
• Aggregation: Less than 10%, as determined by HPLC.
• Recommended Isotype Control: Rat IgG2a kappa Isotype Control (eBR2a), Functional Grade, eBioscience™.