Invitrogen Cyclophilin 40 Polyclonal Antibody, Antigen affinity chromatography Purification

Invitrogen Cyclophilin 40 Polyclonal Antibody, Antigen affinity chromatography Purification

PA1-028 detects cyclophilin D (CyPD) in rat, hamster, canine, mouse, and human tissues.

PA1-028 has been sucessfully used in Western blot procedures. By Western blot, this antibody detects a ~15 kDa protein in rat liver and heart extract, and a ~37 kDa in rat brain extract.

The PA1-028 immunogen is a synthetic peptide corresponding to residues S(42) G N P L V Y L D V D A N(54) C of mature human CyPD. This peptide (Cat. # PEP-104) is available for use in neutralization and control experiments.

This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa.