Invitrogen Cyclophilin 40 Polyclonal Antibody

Invitrogen Cyclophilin 40 Polyclonal Antibody

PA3-023 detects cyclophilin 40 (CyP-40) from human, mouse and rat tissues and cells.

PA3-023 has been successfully used in Western blot and gel shift procedures. By Western blot, this antibody detects a 40 kDa protein representing CyP-40 from rat brain extract.

The PA3-023 immunogen is recombinant human CyP-40 expressed in E. coli.

This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa.