Invitrogen GAPDH Loading Control Monoclonal Antibody (GA1R), Alexa Fluor 555
On demandInvitrogen GAPDH Loading Control Monoclonal Antibody (GA1R), Alexa Fluor 555
GAPDH (Glyceraldehyde-3-phosphate dehydrogenase) is a catalytic enzyme commonly known to be involved in glycolysis. GAPDH exists as a tetramer of identical 37-kDa subunits and catalyzes the reversible reduction of 1,3-bisphosphoglycerate to glyceraldehyde 3-phosphophate in the presence of NADPH. Apart from playing a key role in glycolysis, GAPDH is ubiquitously expressed and displays other activities unrelated to its glycolytic function. GAPDH is reported to be involved in the processes of DNA replication, DNA repair, nuclear RNA export, membrane fusion and microtubule bundling. Studies provide evidence of GAPDH playing an essential part in gene expression observed in apoptosis and as part of the cellular phenotype of age-related neurodegenerative diseases. Further, GAPDH is involved in other cellular processes ranging from membrane fusion, and neuronal apoptosis in cancer. GAPDH is reported to bind to a variety of other proteins, including the amyloid precursor protein, mutations in which cause some forms of Alzheimer's disease (AD), and the polyglutamine tracts of Huntingtin, the protein product aberrant forms of which are causative of Huntington's disease. Associations between GAPDH, actin and tubulin have also be reported. Since GAPDH is expressed at high levels in most tissues, it is useful as protein loading control in Western Blot analysis.
There are no specifications
There are no report
You May Also Like
Invitrogen CD80 (B7-1) Monoclonal Antibody (2D10.4), Functional Grade, 25 mg, eBioscience™
$ 10,212
On demand
Invitrogen IL-2 Monoclonal Antibody (JES6-5H4), APC-eFluor™ 780, 25 µg, eBioscience™
$ On demand
On demand
Invitrogen Rat IgG1 kappa Isotype Control (eBRG1), Super Bright 702, 25 µg, eBioscience™
$ On demand
On demand
Invitrogen 100 µg Ly-6G/Ly-6C Monoclonal Antibody (RB6-8C5), Functional Grade, eBioscience™
$ On demand
On demand
Invitrogen Mouse IgG2a kappa Isotype Control (eBM2a), Functional Grade, 50 µg, eBioscience™
$ 83
On demand
Invitrogen IL-17F Monoclonal Antibody (eBio18F10), PE, 100 µg, eBioscience™
$ On demand
On demand
Invitrogen CD83 Monoclonal Antibody (HB15e), APC-eFluor™ 780, 100 Tests, eBioscience™
$ 408