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Invitrogen IL-22 Monoclonal Antibody (1H8PWSR), PerCP-eFluor 710, 100 µg, eBioscience™

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Order number : 46-7221-82
$ On demand

Invitrogen IL-22 Monoclonal Antibody (1H8PWSR), PerCP-eFluor 710, 100 µg, eBioscience™

The 1H8PWSR monoclonal antibody reacts with mouse interleukin(IL)-22. IL-22 is a 20 kDa member of the IL-10 cytokine family that is secreted primarily by Th17, NK cells, and some other T cells. In in vitro Th17 cultures, induction of IL-22 expression is greater in response to IL-23 than IL-6 or TGF-β, suggesting that this cytokine may be secreted by more fully differentiated Th17 cells in vivo. A heterodimer consisting of IL-10R2 and IL-22R1 serves as the receptor for IL-22. Th17-secreted IL-22 binds to the IL-22 receptor complexon target cells to induce the expression of anti-microbial peptides β-defensin-2 and β-defensin-3. Recently, it was demonstrated that IL-22 is able to protect hosts against bacterial infections of the lungs and gut.

PerCP-eFluor® 710 can be used in place of PE-Cy5, PE-Cy5.5 or PerCP-Cy5.5. PerCP-eFluor® 710 emits at 710 nm and is excited with the blue laser (488 nm). Please make sure that your instrument is capable of detecting this fluorochrome. For a filter configuration, we recommend using the 685 LP dichroic mirror and 710/40 band pass filter, however the 695/40 band pass filter is an acceptable alternative.

Our testing indicates that PerCP-eFluor® 710 conjugated antibodies are stable when stained samples are exposed to freshly prepared 2% formaldehyde overnight at 4°C, but please evaluate for alternative fixation protocols.


Features

  • Excitation: 488 nm; Emission: 710 nm; Laser: Blue Laser.
  • Filtration: 0.2 µm post-manufacturing filtered.
  • Recommended Isotype Control: Rat IgG1 kappa Isotype Control (eBRG1), PerCP-eFluor 710, eBioscience™.
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https://www.thermofisher.com/antibody/product/IL-22-Antibody-clone-1H8PWSR-Monoclonal/46-7221-82

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