Invitrogen™ mirVana™ miRNA Inhibitor, let-7c positive control (5 nmol)
On demandInvitrogen™ mirVana™ miRNA Inhibitor, let-7c positive control (5 nmol)
The mirVana™ miRNA Inhibitor let-7c Positive Control is intended for use as a positive control for mammalian cell culture experiments using mirVana™ miRNA Inhibitors. Endogenous let-7c miRNA has been shown to negatively regulate HMGA2 mRNA in cultured cells. HMGA2 is a ubiquitously expressed, nonhistone, chromatin protein that can modulate gene expression through changes in chromatin architecture. let-7c miRNA down-regulates levels of HMGA2 mRNA. When transfected into human and mouse cell lines, let-7c miRNA inhibitor blocks endogenous let-7c miRNA, resulting in increased levels of HMGA2 mRNA. Thus, let-7c miRNA inhibitor activity can be monitored in human or mouse cells using real-time reverse transcription PCR (RT-PCR) to detect HMGA2 mRNA.
Features
- Display better potency than lead competitor's product
- Offer maximum and consistent effect in vitro at low miRNA inhibitor concentration
- Are non toxic
- Target the most updated Sanger content
- Can be used in vitro and in vivo, offering consistency throughout your entire research project
There are no specifications
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