Invitrogen PDI Monoclonal Antibody (RL90), Alexa Fluor 488

Invitrogen PDI Monoclonal Antibody (RL90), Alexa Fluor 488

Protein disulfide isomerase (PDI) is a multifunctional protein that catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, the protein seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. It may therefore cause structural modifications of exofacial proteins. Inside the cell, PDI seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, it functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, it facilitates aggregation (anti-chaperone activity).

MA3019A488 detects protein disulphide-isomerase (PDI) from human, rat, porcine and mouse tissues as well as hamster cells, The MA3019A488 antigen is purified rat PDI.