Invitrogen™ Silencer™ Select Human Epigenetics siRNA Library

Invitrogen™ Silencer™ Select Human Epigenetics siRNA Library

Epigenetic regulation of gene expression is proving to be key in the development and progression of a host of human diseases. The Silencer™ Select Human Epigenetics siRNA Library contains 1,563 Ambion™ Silencer Select highly potent, chemically-modified siRNAs targeting 521 epigenetic enzymes, including those mediating epigenetic signaling through the acetylation and methylation of histones. This library was designed using the most up-to-date genome databases, including the NCBI RefSeq database and cross-referenced to the Gene Ontology Consortium (GO) database and/or the HUGO Gene Nomenclature Committee (HGNC). The Silencer Select siRNAs are designed using Thermo Fisher Scientific’s leading design algorithms—along with our novel locked nucleic acid (LNA) modifications, this helps to ensure the efficacy, specificity and potency required for accurate and consistent phenotype data for RNAi screening against epigenetic gene knockdown studies.

Features

• Superior efficacy - Reduce off target effects by up to 90% due to latest design algorithms and LNA chemical modifications
• Highest efficiency—Perform knockdown studies with 100-fold more potent siRNAs than currently available siRNAs
• Dependable —Achieve faster discoveries via consistency of gene knockdown and reliability of phenotypic results
• Convenient—Reduce data de-convolution and accelerate target validation with our arrayed format
• Customizable—Choose the best option for your workflow demands, including additional siRNA scales and pooled formats

Contents

• 1563 total siRNAs targeting 521 genes plated onto 96-well plates (18 plates)