Invitrogen™ Silencer™ Select Human Transcription Factor siRNA Library

Invitrogen™ Silencer™ Select Human Transcription Factor siRNA Library

Transcription factors are fast becoming promising drug targets, as they bind to and regulate the transcription of genes. The Silencer™ Select Human Transcription Factor siRNA Library targets genes expressing proteins that bind DNA in a sequence-specific manner to control the rate of transcription of genetic information from DNA to messenger RNA. The Silencer Select Human Transcription Factor siRNA Library contains 5457 Ambion™ Silencer Select highly potent and chemically-modified siRNAs targeting 1819 known transcription factors. This library was designed using the most up-to-date genome databases, including the NCBI RefSeq database and cross-referenced to the Gene Ontology Consortium (GO) database and/or the HUGO Gene Nomenclature Committee (HGNC). The Silencer Select siRNAs are designed using Thermo Fisher Scientific’s leading design algorithms—along with our novel locked nucleic acid (LNA) chemical modifications, this helps to maximize the efficacy, specificity and potency required for RNAi screening against transcription factors.

Features

•  Superior efficacyReduce off target effects by up to 90% due to latest design algorithms and LNA chemical modifications
• Highest efficiency—Perform knockdown studies with 100-fold more potent siRNAs than currently available siRNAs
• Dependable—Achieve faster discoveries via consistency of gene knockdown and reliability of phenotypic results
• Convenient—Reduce data de-convolution and accelerate target validation with our arrayed format
• Customizable—Choose the best option for your workflow demands, including additional siRNA scales and pooled formats

Contents

• 5457 total siRNAs targeting 1819 genes plated onto 96-well plates (63 plates)