Invitrogen™ Silencer™ Select Human Tumor Suppressor siRNA Library

Invitrogen™ Silencer™ Select Human Tumor Suppressor siRNA Library

Mutations that cause a loss or reduction in gene function can result in the progression to cancer, usually in combination with other genetic changes. Tumor suppressor genes, or anti-oncogenes, can protect cells on the path to becoming cancerous. The Silencer™ Select Human Tumor Suppressor siRNA Library contains 2,235 Ambion™ Silencer Select siRNAs targeting 745 tumor suppressor genes. This library of highly potent, chemically-modified siRNAs was designed using the most up-to-date genome databases, including the NCBI RefSeq database and cross-referenced to the Gene Ontology Consortium (GO) database and/or the HUGO Gene Nomenclature Committee (HGNC) as well as the Tumor Suppressor Gene Database (TSGene). Silencer Select siRNAs are designed with Thermo Fisher Scientific’s leading design algorithms and locked nucleic acid (LNA) modifications to help ensure efficacy, specificity and potency and provide accurate and consistent phenotype data for RNAi screening against tumor suppressor genes.

Features

• Superior efficacy—Reduce off target effects by up to 90% due to latest design algorithms and LNA chemical modifications
• Highest efficiency—Perform knockdown studies with 100-fold more potent siRNAs than currently available siRNAs
• Dependable—Achieve faster discoveries via consistency of gene knockdown and reliability of phenotypic results
• Convenient—Reduce data de-convolution and accelerate target validation with our arrayed format
• Customizable—Choose the best option for your workflow demands, including additional siRNA scales and pooled formats

Contents

• 2235 total siRNAs targeting 745 genes plated onto 96-well plates (27 plates)