MDS (EGR1/D5S630) Chromosome and Gene Anomaly Probe Detection Kit (IVD)

MDS (EGR1/D5S630) Chromosome and Gene Anomaly Probe Detection Kit (IVD)

Myelodysplastic syndrome (MDS) is a group of heterogeneous diseases that are generally considered to originate from hematopoietic stem cells and belong to malignant clonal diseases. Studies have shown that 40% to 60% of patients with MDS have non-randomized chromosomal anomalies, of which - the most common are 5/5q-, -7/7q-, +8, 20q-, and -Y. Among the common chromosomal anomalies’ in patients with MDS, some chromosomal anomalies have specific diagnostic value. Immunosuppressive therapy is  effective in some patients with simple +8, 20q-, or Y-; karyotype analysis also has important value in the classification, treatment, and prognosis of MDS, such as single Y-, 5q- or 20q- patients’ have a good prognosis, while patients with complex chromosomal anomalies (≥3 anomalies) or chromosome 7 anomalies have a poorer prognosis. Patients with other anomalies have a moderate prognosis. These anomalies are of great significance in the diagnosis, treatment, and prognosis of MDS.