MYC(8q24) Gene Amplification Probe Detection Kit (IVD)

MYC(8q24) Gene Amplification Probe Detection Kit (IVD)

Post-radiation cutaneous angiosarcoma is a malignancy associated with very poor outcome and is consequently treated aggressively. Conversely, atypical vascular lesions are also associated with radiation therapy but are considered to be benign and do not require aggressive management. Therefore, the differentiation of these neoplasms is of considerable clinical importance. Post-radiation cutaneous angiosarcomas are characterized by high-level amplification of MYC, whereas reactive and benign vascular lesions do not show amplification of MYC. Similar diagnostic difficulties arise in the setting of primary cutaneous vascular lesions. A subset of primary cutaneous angiosarcomas also shows high-level MYC amplification, which can be useful in the differentiation from benign primary cutaneous vascular lesions.