Thermo Scientific™ DTME (dithiobismaleimidoethane)
On demand
Order number :
22335
Thermo Scientific™ DTME (dithiobismaleimidoethane)
Thermo Scientific Pierce DTME is a mid-length, maleimide crosslinker for reversible covalent conjugation between sulfhydryl groups (e.g., protein or peptide cysteines) by reduction of the disulfide bond in the center of the spacer arm.
Features
- Reactive groups: maleimide (both ends)
- Reactive towards: sulfhydryl groups
- Long (13.3A), cleavable, sulfhydryl-to-sulfhydryl crosslinker, composed of maleimide groups and 11-atom disulfide spacer arm
- Water-insoluble—dissolve first in DMF or DMSO, then add to aqueous reaction buffers
- Cleavable by reduction of disulfide spacer arm with DTT, TCEP or other reducing agent
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