Thermo Scientific™ iodoTMTsixplex™ Isobaric Label Reagent Set, 5 x 0.2 mg

Thermo Scientific™ iodoTMTsixplex™ Isobaric Label Reagent Set, 5 x 0.2 mg

Thermo Scientific iodoTMTsixplex Label Reagents enable concurrent identification and multiplexed quantitation of proteins in different samples using tandem mass spectrometry. The iodoTMT™ Reagents are sets of isobaric (mass and structure) isomers that are iodoacetyl-activated for covalent, irreversible labeling of sulfhydryl (—SH) groups. Similar to iodoacetamide, iodoTMT Reagents react specifically with reduced cysteines (Cys) in peptides and proteins. IodoTMT Reagents can be differentiated by mass spectrometry (MS), enabling quantitation of the relative abundance of cysteine modifications, such as S-nitrosylation, oxidation and disulfide bonds, in cultured cells grown or treated with different conditions.

For use with: Mass Spectrometer

Features

• Specific—only reacts with sulfhydryl groups (reduced, unmodified cysteine residues)
• Irreversible—labeled proteins and peptides are not susceptible to reducing agents
• Flexible—options for duplex isotopic (MS) or sixplex isobaric (MS/MS) quantitation
• Versatile—can be used to study cysteine modifications (e.g. di-sulfide bridges, S-nitrosylation)

Contents

• iodoTMT6-126 Label Reagent, 0.2 mg
• iodoTMT6-127 Label Reagent, 0.2 mg
• iodoTMT6-128 Label Reagent, 0.2 mg
• iodoTMT6-129 Label Reagent, 0.2 mg
• iodoTMT6-130 Label Reagent, 0.2 mg
• iodoTMT6-131 Label Reagent, 0.2 mg