Thermo Scientific™ Pierce™ SATP (N-succinimidyl-S-acetylthiopropionate)

Thermo Scientific™ Pierce™ SATP (N-succinimidyl-S-acetylthiopropionate)

Thermo Scientific Pierce SATP is a long-chain (4.1 angstrom spacer arm) reagent for covalent modification of primary amines and addition of a protected yet exposable sulfhydryl group, enabling heterobifunctional crosslinking strategies.

Features

• Adds a protected sulfhydryl that can be deprotected by hydroxylamine
• Allows long-term storage of the sulfhydryl-modified molecule
• Offers more steric freedom than SATA for the unmasked sulfhydryl group
• Forms cleavable disulfide bonds with other sulfhydryl-containing molecules
• Reacts with primary amines (e.g., lysine residues proteins) to form stable amide bonds
• Preserves protein activity with its mild, non-denaturing reaction cdonditions