Thermo Scientific™ SIA (succinimidyl iodoacetate)
On demand
Order number :
22349
Thermo Scientific™ SIA (succinimidyl iodoacetate)
Thermo Scientific Pierce SIA is a very short (1.5 angstrom) crosslinker for amine-to-sulfhydryl conjugation via N-hydroxysuccinimide (NHS) ester and iodoacetyl reactive groups.
Features
- Reactive groups: NHS ester and iodoacetyl
- Reactive toward: amino and sulfhydryl groups
- Shortest sulfhydryl-reactive and amine-reactive heterobifunctional crosslinker available; compare to SIAB
- NHS ester reacts with primary amines at pH 7-9 to form a stable amide bond
- Iodoacetyl group reacts with sulfhydryl groups at pH > 7.5 to form stable thioether bond
- Non-cleavable
- Water-insoluble (dissolve first in DMF or DMSO)
There are no specifications
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