Invitrogen Granzyme B Monoclonal Antibody (NGZB), PE-Cyanine7, 25 µg, eBioscience™
On demandInvitrogen Granzyme B Monoclonal Antibody (NGZB), PE-Cyanine7, 25 µg, eBioscience™
This NGZB monoclonal antibody reacts with mouse Granzyme B, which is a member of the granzyme serine protease family. Granzyme B is found in the granules of cytotoxic T cells and NK cells. Granzyme B has also been described as CGL1 (cathepsin G-like-1), a serine protease expressed only in cytotoxic T-lymphocytes after cell activation, and CTLA-1 (cytotoxic T lymphocyte-associated serine esterase 1) based on identification of mRNA in various cytotoxic T cells, but not observed in non-cytotoxic lymphoid cells. Granzyme B is crucial for the rapid induction of target cell death by apoptosis, induced by interaction with cytotoxic T cells. The receptor involved has been identified as mannose 6-phosphate receptor. This receptor functions as a death receptor for Granzyme B during cytotoxic T cell-induced apoptosis. This NGZB monoclonal antibody does not crossreact to human Granzyme B nor is staining blocked with GB11, suggesting it recognizes a different epitope.
Features
- Light sensitivity: This tandem dye is sensitive photo-induced oxidation. Please protect this vial and stained samples from light.
- Fixation: Samples can be stored in IC Fixation Buffer (100 µL cell sample + 100 µL IC Fixation Buffer) or 1-step Fix/Lyse Solution for up to 3 days in the dark at 4°C with minimal impact on brightness and FRET efficiency/compensation. Some generalizations regarding fluorophore performance after fixation can be made, but clone specific performance should be determined empirically.
- Excitation: 488-561 nm; Emission: 775 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.
- Filtration: 0.2 µm post-manufacturing filtered.
- Recommended Isotype Control: Rat IgG2a kappa Isotype Control (eBR2a), PE-Cyanine7, eBioscience™.
There are no specifications
There are no report
You May Also Like
![](https://laboshop.ae/public/storage/files/663053f9-8409-4f76-8380-b03c66ac1f17.png)
Invitrogen 100 µg Rat IgG2a kappa Isotype Control (eBR2a), PE-eFluor 610, eBioscience™
$ On demand
On demand
![](https://laboshop.ae/public/storage/files/a915b6c0-7abb-4836-9dbb-0771753b8428.png)
Invitrogen CD49f (Integrin alpha 6) Monoclonal Antibody (eBioGoH3 (GoH3)), Unconjugated, 500 µg, eBioscience™
$ 309
On demand
![](https://laboshop.ae/public/storage/files/6a13f6b9-f1a0-4e8f-b288-360e9d9eb73f.png)
Invitrogen 100 µg CD140b (PDGFRB) Monoclonal Antibody (APB5), Alexa Fluor 488, eBioscience™
$ On demand
On demand
![](https://laboshop.ae/public/storage/files/e6bfa6c1-9fb6-4d3f-971e-7bddcc501222.png)
Invitrogen CD4 Monoclonal Antibody (RM4-5), eFluor™ 450, 25 µg, eBioscience™
$ On demand
On demand
![](https://laboshop.ae/public/storage/files/6b8bdb89-ebaf-413a-a8fe-d71e43f57107.png)
Invitrogen TLR4/MD-2 Complex Monoclonal Antibody (MTS510), Biotin, 50 µg, eBioscience™
$ On demand
On demand
![](https://laboshop.ae/public/storage/files/de7c928e-5ffe-4711-a7e2-1574200e0361.png)
Invitrogen CD54 (ICAM-1) Monoclonal Antibody (HA58), Super Bright™ 436, 25 Tests, eBioscience™
$ 204
On demand
![](https://laboshop.ae/public/storage/files/7b95e232-cced-4cb8-b9bb-6e3d9230b132.jpg)
Invitrogen™ ReadyProbes™ Endogenous HRP and AP Blocking Solution (1X)
$ On demand